Lately I have been using a software package called ESMPy to interpolate weather data on one grid to another. There is a learning curve with this software and things are not as Pythonic as one might hope. The C backbone tends to show through in the syntax a bit. Overall, though, it is a nice tool and is less clunky than GEMPAK. Luckily for you I have put together a ESMPy tutorial in a Jupyter notebook. Come and see it on github.